By K. Walker,
This would explain why the jabbed seem to take longer to recover from a milder version of the virus.
A new report published in the medical journal Science Immunology just days before Christmas innocuously titled, “Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination” shows some disturbing data regarding the effect of multiple mRNA shots on the immune system.
A thread by one of the authors admits an “unexpected rise” in a specific type of antibody — Immunoglobin G4 (IgG4) — after the third mRNA shot.
The immune response after the booster appears to shift so that the body produces more IgG4 antibodies and fewer other antibodies that are more effective at attacking the SARS-CoV-2 virus.
The change could mean that people who have had their three (or more) mRNA shots are more susceptible to COVID infection as well as prolonged — and perhaps more severe — illness once they do contract the virus.
These results are specific to the mRNA shots.
Here is one of the authors of the study explaining the findings.
In the peer-reviewed manuscript, relative numbers (panel c) of IgG4 highlight that shortly after 3rd vaccination, about 20% of IgG is IgG4, which is further boosted through breakthrough infections (grey circles) at follow-up (FU) to up to 40-80%. This is very unusual. 3/11 pic.twitter.com/LLufy9MBjj
— Kilian Schober (@kischober) December 22, 2022
So what? Fab function is unchanged. We, as many others, saw improved antibody avidity and cross-neutralization after 3rd vs. 2nd vaccination. However, Fc effector functions are indeed deteriorated (!). Next to phagocytosis, we now also report this for complement deposition. 5/11 pic.twitter.com/SZ5n6GHI2L
— Kilian Schober (@kischober) December 22, 2022
In one tweet, Schober did try to downplay the attention that the pre-print study is getting among “aNtI-vAxXeRs” by insisting that the mRNA shots have (essentially) been “safe and effective.”
In a later tweet, however, he admits that since the mRNA technology is being explored for treating autoimmune diseases and cancer, the increase of IgG4 “clearly requires further investigation.”
Again, Fab functions like neutralization are fully preserved upon class switch to IgG4. So is the class switch irrelevant in terms of consequences on subsequent infections? We don't know. Fc effector functions could be critical for viral clearance (sterile immunity)… 7/11
— Kilian Schober (@kischober) December 22, 2022
Given the enormous potential of mRNA vaccines for the fields of infectious diseases, autoimmunity and cancer, the induction of IgG4 antibodies clearly requires further investigation. Deciphering the precise immunological mechanism underlying this class switch will be fun! 9/11
— Kilian Schober (@kischober) December 22, 2022
We are also grateful to @BMBF_Bund @Covim_Netzwerk @dfg_public @DZIF_ and @EKFStiftung for supporting this work. Funders had no influence on the study design and data interpretation. Lastly, thanks go to editor @IforRWilliams and our 4 critical, but constructive reviewers. 11/11
— Kilian Schober (@kischober) December 22, 2022
Meanwhile, the study clearly troubles some of the prominent pro-vax voices.
Important work on the shift in IgG classes with repeated mRNA vax dosing. Significance isn’t clear and this needs study. https://t.co/8dy8owagNO
— David Fisman (@DFisman) December 26, 2022
Over the last two days, I’ve read articles and Substack posts about the significance of the immune system’s shift to producing IgG4 post-booster written by doctors, scientists, journalists, and the average Joe just trying to wrap their heads around what the heck is going on.
Independent journalist Alex Berenson explained it this way, “IgG4 has been shown to become more common in people chronically exposed to allergens. Beekeepers famously develop higher levels of IgG4 antibodies to bee venom over time, for example.”
Substack author Igor Chudov explains this study’s significance in straightforward terms.
Our immune systems are complicated. We do need to fight dangerous replicating pathogens, such as viruses or bacteria. At the same time, we also face harmless inert substances, such as tree pollen, that sometimes cause inflammatory reactions called allergies.
To deal with these harmless substances, our immune system has a particular class of antibodies, called IgG4, that do the opposite of what we are used to hearing: they bind to allergens and tell our immune cells to ignore them rather than cause inflammation.
He then explains that the mRNA shots are working like allergy shots.
I had many pollen allergies. Every spring was unpleasant. I decided to go to an allergist and take allergy shots, which amounted to repeatedly injecting allergens into me. As a result of these repeat antigen shots, my immune system developed non-inflammatory IgG4 antibodies, which mark pollen as a harmless substance to the rest of my immune system and prevent allergic inflammation and nasty symptoms.
There is something important, though: pollen does not replicate.It is a good idea not to have inflammation in response to pollen. It is a bad idea, however, to train our immune system to ignore replicating pathogens such as Sars-Cov-2.
Sometimes memes can get the idea across in a way that all the technical language can’t.
A very SIGNIFICANT research paper dropped on 22 Dec which ROCKED even the pro-vax experts! @ichudov wrote a very nice commentary on it here… https://t.co/c2KG8JXD6H
BUT, for those of us who are more visually inclined…
This 2 mins clip explains it all!! pic.twitter.com/A0YHwYT3MG— aussie17 (@_aussie17) December 27, 2022
3. Mr “Pro-Vax” Topol himself is baffled
“The clinical significance is unknown” pic.twitter.com/P8FNy6fzM0— aussie17 (@_aussie17) December 27, 2022
Berenson concluded his article on Substack with this:
…[I]f the mRNAs are truly generating broad “immune tolerance” to a virus that continues to mutate its spike and make all our anti-spike protein antibodies less potent (as Omicron has), the long-term consequences are potentially frightening.
At the least, this paper offers more evidence that mRNA booster campaigns need to be immediately restricted. And scientists need to examine whether people with high post-vaccination levels of IgG4 antibodies are becoming sicker than people with lower levels. If they are, we need an immediate effort to look for tools to reverse or slow switching to IgG4 at the cellular level.
Physicians will also have to be on the lookout for a spike in IgG4 related disease, which generally manifests as autoimmune disorders and is usually fairly responsive to steroids. Source: Unreported Truths (Dec. 27, 2022)
It’s important to note that this doesn’t mean that boosted people cannot mount an immunological response if they are infected by COVID-19; it just means that it may be a long, lingering illness and put a strain on their immune system. In addition, it potentially puts them at risk for organ damage from the virus because their immune system is taking a long time to fight off the virus.
What does that mean long term for a virus that will soon become an endemic virus like the flu? Who knows. Only time will tell.
Cross-Posted with Clash Daily
